PROCESS FOR PREPARING 1-(AMINOMETHYL) CYCLOHEXANEACETIC ACID Russian patent published in 1995 - IPC

FIELD: in medicine as an antispasmodic. SUBSTANCE: a new process for preparing 1-(aminomethyl) cyclohexaneacetic acid of the general formula: C₆H₁₀(CH₂COOH)(CH₂NH₂) .. Reagent 1: 1-(cyanodicyclohexyl) acetic acid derivative of the formula: C₆H₁₀(CN)(CH₂Z) , prepared by decarboxylation of dialkyl ester of (1-cyanocyclohexyl) malonic acid of the formula: C₆H₁₀(CN)[CH(COOR)₂) (III) or a compound of the formula II wherein Z is a CN group. Reagent 2: benzyl alcohol of the formula IV: O= , M= , n = R¹C₆H₄CH₂OH or lower aliphatic alcohol. Reaction conditions: compound II wherein Z is COOR, R-C₁-C₄-alkil or compound II in which Z is a CN group is reacted with a benzyl alcohol IV or lower aliphatic alcohol in the presence of a basic catalyst or mineral acid followed by aqueous hydrolysis of the compound in which Z is CN to obtain a compound of the formula: C₆H₁₀(CN)(CH₂COOPhR¹) , wherein R' is as defined above, which compound is subjected to catalytic hydrogenation. EFFECT: improved properties of the title compound. 5 cl