METHOD OF SYNTHESIS OF 23-(C-C-ALKYLOXIMES)-L,L-F-28249 Russian patent published in 1995 - IPC

FIELD: chemical technology. SUBSTANCE: product: 23-(C₁-C₆-alkyloximes)-LL-F-28249. Reagent 1: LL-F-28249. Reagent 2: p-nitrobenzoyl chloride. Reagent 3: 5-o-(p-nitrobenzoyl)-LL-F-28249. Reagent 4: acetic anhydride and dimethylsulfoxide. Conditions of oxidation process: in the presence of pyridine and acid, and prepared derivative of 5-o-(p-nitrobenzoyl)-23-oxo-LL-F-28249 in crystalline state is oxylated at any order with C₁-C₆-alkoxyamine or its salt following deprotection. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 2 tbl