FIELD: organic chemistry. SUBSTANCE: product: 1-(2′-cyanoethyl)-4-methoxy-5-amino-6-thio-1,6-dihydropyrimi- dine, C7H10N4OS, white crystalline compound, b. p. is 165-166 C (in aqueous ethanol). Reagent 1: 4-methoxy-5-amino-6-mercaptopyrimidine. Reagent 2: acrylonitrile or 3-halogenpropionitrile. Process is carried out in aqueous medium or in organic solvent in the presence of basic catalyst at 20-80 C. Yield is 52-69%. Method is used for synthesis of bioactive compounds. EFFECT: improved method of synthesis. 1 tbl
| Title |
Year |
Author |
Number |
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- Rjabova S.Ju.
- Alekseeva L.M.
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- Faermark I.F.
- Shvarts G.Ja.
|
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- Mel'Man A.I.
- Tomchin A.B.
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- Smirnov A.V.
|
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- Levina V.I.
- Shvedov V.I.
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|
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- Mashkovskij M.D.
- Juzhakov S.D.
- Dolgun O.V.
- Denisov A.V.
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|
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- Donn G. Vishka
- Gari Dzh. Klik
- Dehvid R. Grejber
- Stiven Tomas Shljakhter
- Majkl Dzh. Merfi
- Dzhoel Morris
- Richard S. Tomas
|
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0 |
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|
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- Rjabova S.Ju.
- Trofimkin Ju.I.
- Granik V.G.
- Faermark I.F.
- Shvarts G.Ja.
|
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- Afanas'Eva V.L.
- Glushkov R.G.
- Erofeev Ju.V.
- Kovaleva S.S.
|
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- Sokolova A.S.
- Bogomolova N.S.
- Romanova O.B.
- Granik V.G.
|
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- Dekhanova O.A.
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- Gojzman M.S.
- Ukolova Zh.I.
|
RU2087902C1 |
