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2 024 525

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C1

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IPC

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Application

4903336/04, 1991-01-21

(22)

Actual filing date

1991-01-21

(45)

Published

1994-12-15

(72)

Inventor

Velezheva V.S.Mel'Man A.I.Tomchin A.B.Marysheva V.V.Spivakova R.P.Smirnov A.V.

(73)

Holder

Tsentr Po Khimii Lekarstvennykh Sredstv

4-ACETYL -7- BROMOIMIDAZO -[4,5-B] -INDOLE -2-THIONE SHOWING CAPABILITY TO RECOVERY WORKING CAPACITY, AND A METHOD OF ITS SYNTHESIS Russian patent published in 1994 - IPC

Abstract RU 2024525 C1

FIELD: organic chemistry. SUBSTANCE: product of the general formula (I) (image). Reagent 1: 1-acetyl -2-amino -5-bromo-3- indolinone in the form of hydrochloride. Reagent 2: potassium thiocyanate. Reagent 3: 1-acetyl -5-bromo- 2-thioureido -3-indolinone. Conditions: cyclization in the mixture of phosphorus anhydride and 87% phosphoric acid. Synthesized substance is used as medicinal preparation. EFFECT: improved method of synthesis. 3 cl, 2 tbl

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RU 2 024 525 C1

Authors

Velezheva V.S.

Mel'Man A.I.

Tomchin A.B.

Marysheva V.V.

Spivakova R.P.

Smirnov A.V.

Dates

1994-12-15—Published

1991-01-21—Filed

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