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2 026 287

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C1

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IPC

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Application

4950026/04, 1991-06-28

(22)

Actual filing date

1991-06-28

(45)

Published

1995-01-09

(72)

Inventor

Rjabova S.Ju.Trofimkin Ju.I.Granik V.G.Faermark I.F.Shvarts G.Ja.

(73)

Holder

Tsentr Po Khimii Lekarstvennykh Trav

DERIVATIVES OF PYRROLINE-2-ONE-4 OR INDOLINONE-3 SHOWING ANTIHYPERTENSIVE ACTIVITY AND A METHOD OF THEIR SYNTHESIS Russian patent published in 1995 - IPC

Abstract RU 2026287 C1

FIELD: organic chemistry. SUBSTANCE: product derivatives of pyrroline-2-one-4 or indolinone-3 of the general formula (I) (1-21) where R - COOC2H5, R1 - CH3, R2+ R3 - (CH2)5 (1); R2+R3 - CH2CH2OCH2CH2 (2); R2 - H, R3 - CH2C6H3 (3); R2 - H, R3 - CH2C6H4-OCH3-4 (4); R2 - H, R3 - CH2C6H3-(OCH3)2-3,4 (5); R + R1 - CH=CH-CH=CH, R2=R3 - H (6); R2 - H, R3 - (CH2)6 (7); R2 - H, R3 - CH2CH2N(C2H5)2 (8); R2 - H, R3 - CH2CH(OH)CH2OH (9); R2+R3 - CH2CH2OCH2CH2 (10); R2+R3 - CH2CH2N(CH3)CH2CH2 (11); R2+R3 - (12); R2 - H, R3 - CH2C6H5/ (13); R2 - H, R3 - CH2C6H5-OCH3-4 (14); R2 - H, R3 - CH2C6H3(OCH3)2- 3,4 (15); R2 - H, R3 - CH(CH3)C6H5 (16); R2 - H, R3 - CH2CH2C6H5 (17); R2 - H, R3=CH2CH2C6H3(OCH3)2 -3,4 (18); R2 - H, R3 - CH(CH3)CH2C6H5 (19); R2 - H, R3= C6H5 (20); R2 - H, R3 - C6H4(OCH3)-4 (21). Reagent 1: derivatives of pyrrolyl- or indolylacrylic acid of the general formula (II) where R and R1 mean indicated meanings. Reagent 2: amine of the general formula NH(R2)(R3) where R2 and R3 as indicated above. Reaction conditions: in the medium of lower alcohol (such as isopronanol), or aromatic hydvocarbon (such as benzenl), at 80-100C. EFFECT: improved method of synthesis. 3cl, 2 tbl

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RU 2 026 287 C1

Authors

Rjabova S.Ju.

Trofimkin Ju.I.

Granik V.G.

Faermark I.F.

Shvarts G.Ja.

Dates

1995-01-09—Published

1991-06-28—Filed

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