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2 008 308

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C1

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IPC

(21) (22)

Application

4950027/04, 1991-06-28

(22)

Actual filing date

1991-06-28

(45)

Published

1994-02-28

(72)

Inventor

Rjabova S.Ju.Alekseeva L.M.Granik V.G.Faermark I.F.Shvarts G.Ja.

(73)

Holder

Tsentr Po Khimii Lekarstvennykh Sredstv

INDOLIN-3-ONE DERIVATIVES WITH ANTIHYPERTENSIVE ACTIVITY AND PROCESS FOR PREPARATION THEREOF Russian patent published in 1994 - IPC

Abstract RU 2008308 C1

FIELD: medicine. SUBSTANCE: the end product is indolin-3-one derivatives of general formula I represented in the description of the invention, wherein R=R1=CH3; R+R1=(CH2)5. Reagent 1: 2-dialkylaminomethyleneindolin-3-ones of general formula II represented in the description of the invention, wherein R and R1 are as indicated above. Reagent 2: malonic acid nitrile. Reaction conditions: reaction of reagents is carried out in inert solvent under reflux. EFFECT: high antihypertensive activity. 1 cl, 1 tbl

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RU 2 008 308 C1

Authors

Rjabova S.Ju.

Alekseeva L.M.

Granik V.G.

Faermark I.F.

Shvarts G.Ja.

Dates

1994-02-28—Published

1991-06-28—Filed

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