FIELD: organic chemistry. SUBSTANCE: product of the formula (1) where R′-C2-C6-alkenyl, C2-C6-alkynyl or group of the formula (2) where n - whole number 0-3 involving both end meanings; R2 - H, C1-C6-alkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkyl-group of the formula (3) or (4) where n is indicated above. R3 - H or C1-C6-alkyl; R4 and R5 - H or together form bond; R6 and R7 every - H or together form group -S, or one of radicals: R6 and R7 - H, and other - groups OH or -SCH; X - group of the formula (5) , m = 0, 1 or 2; Q - NR8 where R8 - H, C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, -SO2CH3 or -(CH2)n-Y where n is indicated above; Y - cyano, OR9, -C(O)R10, -NR11R12/ , -S(C1-C4)-alkyl, or group of the formula (6) where R9 - H or C1-C4-alkyl, or group -C(= O)-C1-C4-alkyl; R10 - C1-C4-alkyl, C1-C4-alkoxy, or -NH2; R11 and R12 independently each of other - H, C2-C6-alkenyl; C2-C6-alkynyl-C1-C6-alkyl, -(CH2)qOH, -(CH2)q-N(C1-C4-аlkyl)2, -(CH2)q-S(C1-C4)alkyl, or group of the formula (7) where n is indicated above, and q - whole number 1-6 involving both end meanings; or R11 and R12 together form morpholine, piperidyl, piperazinyl or N-methylpiperazinyl ring; or its pharmaceutically acceptable salts. Reagent 1: compound of the formula (8) . Reagent 2: compound of the formula (9) . Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 tbl
Authors
Dates
1995-06-09—Published
1990-12-20—Filed