FIELD: medicine. SUBSTANCE: free bases A-82846 A or A-82846 B are used as reagent 1. Aldehyde having formula HC(O)Ro where Ro is H, alkyl C1-C11 or CH(C6H5), (CH2)n-1C6H4R4 group where n is 1-3; R4-H, C1-C8 alkyl, C1-C8 alkoxy, NR5R6, R5 and R6 being hydrogen or C1-C3 alkyl independently is used as reagent 2. Thus prepared Schiff base is reduced to prepare N-alkyl derivative. EFFECT: improves efficiency of the method. 5 cl, 9 tbl
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