METHOD OF PURIFICATION OF INSULIN AND/OR ITS DERIVATIVES Russian patent published in 1995 - IPC

Abstract RU 2037500 C1

FIELD: biotechnology. SUBSTANCE: method involves chromatography in aqueous buffer solvents which contain organic, mixing with water solvents on lipophilic modified silica gel. Aqueous buffer solvents contain amphoteric ions or pH value of solvent mixture near isoelectric point of insulin to be purified or its derivative in the presence of amphoteric ions. EFFECT: retained bioactivity of proteins to be purified, accelerated and simplified method of purification. 7 cl, 2 tbl

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RU 2 037 500 C1

Authors

Rajner Dikkhardt[De]

Bernkhard Unger[De]

Leonard Khehfner[De]

Dates

1995-06-19—Published

1991-09-03—Filed