FIELD: medicine, endocrinology, peptides, pharmacy. SUBSTANCE: invention describes derivatives of insulin of the general formula (I) 
where Z means histidine residue or peptide with 2-35 genetically encoded amino acid residues containing 1-5 histidine residues that show the enhanced capacity to bind zinc and useful for production of pharmaceutical compositions used for treatment of diabetic patients. Insulins of the formula (I) form complexes with zinc that contain insulin hexamer with about 5-9 moles of zinc per a hexamer. EFFECT: valuable properties. 16 cl, 11 ex
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