FIELD: medicine. SUBSTANCE: method involves culturing pig spinal cord cells in nutrient medium, separating supernatant by centrifuging, exposing it to ultrafiltration on membranes having 10 000 Dalton permeability threshold at a temperature from 4 C to the room temperature, concentrating by means of lyophilization, performing gel filtration chromatography with G-25 Sephadex. The separated fractions of 600-3000 Dalton molecular mass are repeatedly concentrated by means of lyophilization. EFFECT: higher immunostimulating activity; lowered therapeutic doses. 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING STIMULANT OF ANTIBODY PRODUCENTS | 0 |
|
SU1005790A1 |
| METHOD FOR PREPARING "MIELOPID" | 2003 |
|
RU2232584C1 |
| ANTITUMOR AGENT | 1993 |
|
RU2067870C1 |
| AGENT "SERAMIL" FOR TREATMENT OF SICKNESS OF BACTERIAL NATURE | 2002 |
|
RU2210383C1 |
| HEXAPEPTIDE (BIVALFOR) SHOWING ANTITUMOR ACTIVITY | 1993 |
|
RU2064935C1 |
| METHOD OF PRODUCING BIOLOGICALLY ACTIVE PEPTIDES | 2014 |
|
RU2601126C2 |
| RECOMBINANT PROTEIN REC-MP, CONTAINING SEQUENCE OF MYELOPEPTIDES FOR TREATING SECONDARY IMMUNODEFICIENCY CONDITIONS | 2014 |
|
RU2585494C2 |
| POLYPEPTIDE PREPARATION OUT OF CHICKEN BURSA, METHOD FOR ITS OBTAINING AND PHARMACEUTICAL COMPOSITION BASED UPON THIS PREPARATION | 2000 |
|
RU2180592C1 |
| METHOD OF PREPARING INTERFERON FROM SWINE LEUKOCYTES | 1992 |
|
RU2057545C1 |
| METHOD OF PREPARING CELLULAR PROLIFERATION INHIBITOR | 1993 |
|
RU2067866C1 |
