FIELD: medicine, oncology, peptide chemistry. SUBSTANCE: product: hexapeptide of the formula OH-C-Leu-Val-Val-Tyr-Pro-Trp, empirical formula is C42H57N7O9. Indicated peptide abolishes toxic effect of tumor cells on functional activity of T-lymphocytes, stimulates production of endogenous mediating agents (interlekin-2) by T-lymphocytes, nontoxic. Hexapeptide is synthesized by solid-phase method splicing peptide chain from N-terminal. Peptide formulation after its removal from resin and deblocking is carried out with formic acid. Synthesized peptide is purified by method of reversed-phase chromatography. Peptide is used for preparation making used in antitumor therapy. EFFECT: improved method of synthesis.
| Title | Year | Author | Number |
|---|---|---|---|
| ANTITUMOR AGENT | 1993 |
|
RU2067870C1 |
| IMMUNOMODULATOR WITH ANTITUMOR ACTIVITY AND DRUG BASED ON THE SAME | 2005 |
|
RU2283663C1 |
| AGENT "SERAMIL" FOR TREATMENT OF SICKNESS OF BACTERIAL NATURE | 2002 |
|
RU2210383C1 |
| PEPTIDE-IMMUNOREGULATOR (VERSIONS), MEDICINAL AGENT COMPRISING PEPTIDE-IMMUNOREGULATOR | 1998 |
|
RU2198178C2 |
| PEPTIDE WITH ANTIPROLIFERATIVE ACTIVITY AND PHARMACEUTICAL COMPOSITION FOR TREATING PROLIFERATIVE DISEASES | 2007 |
|
RU2446174C2 |
| IMMUNOCYTOKINES BASED ON IL-15 AND IL-15Rα OF THE SUSHI DOMAIN | 2012 |
|
RU2763298C2 |
| T- CELLS WITH COSTIMULATING CHIMERIC ANTIGEN RECEPTOR TARGETING IL13Rα2 | 2015 |
|
RU2749922C2 |
| METHOD FOR INCREASING NUMBER OF LYMPHOCYTES IN TUMOURS USING HYBRID PROTEIN IL-7 | 2020 |
|
RU2822396C1 |
| MESOTHELINIC CAR RECEPTORS AND USE THEREOF | 2020 |
|
RU2822193C2 |
| INTRODUCTION OF CONSTRUCTED T CELLS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCER | 2017 |
|
RU2757308C2 |
