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2 585 494

(13)

(51)

IPC

C07K19/00(2006-01-01)

C07K7/06(2006-01-01)

A61K38/08(2006-01-01)

(21) (22)

Application

2014137558/10, 2014-09-17

(24)

Start date

2014-09-17

(22)

Actual filing date

2014-09-17

(45)

Published

2016-05-27

(72)

Inventor

Petrov Rem ViktorovichMartynov Aleksandr IgorevichStepanenko Rodion NikolaevichGasanov Vagif Ali OglyShevale Aleksandr Fedorovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchnyj Tsentr Institut Immunologii" Federalnogo Mediko-Biologicheskogo Agentstva Rossii

RECOMBINANT PROTEIN REC-MP, CONTAINING SEQUENCE OF MYELOPEPTIDES FOR TREATING SECONDARY IMMUNODEFICIENCY CONDITIONS Russian patent published in 2016 - IPC C07K19/00 C07K7/06 A61K38/08

Abstract RU 2585494 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to production of recombinant protein containing sequences of myelo-peptides, and can be used for treatment of secondary immunodeficiencies. Recombinant protein (REC-MP) is constructed by alternation of short active myelopeptides MP-1 (FLGFPT), MP-2 (LVVYPW), MP-3 (LVCYPQ) and MP-4 (FRPRMTP), alternating with thrombin and urokinase recognition sites.

EFFECT: invention allows to increase clinical effectiveness of treatment of secondary immunodeficiencies by more evident stimulation of antibodies formation, by increasing the number of B-lymphocytes expressing CD25 and CD69 on their surface.

5 cl, 4 dwg, 2 tbl, 6 ex

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RU 2 585 494 C2

Authors

Petrov Rem Viktorovich

Martynov Aleksandr Igorevich

Stepanenko Rodion Nikolaevich

Gasanov Vagif Ali Ogly

Shevale Aleksandr Fedorovich

Dates

2016-05-27—Published

2014-09-17—Filed