FIELD: biological engineering. SUBSTANCE: polypeptides possessing properties of hepatitis C virus internal antigen are obtained. The polypeptides are capable of binding antibodies to hepatitis C virus Cor-antigen. After having been administered to experimental animals, the polypeptides invoke formation of specific antibodies to hepatitis C virus Cor-antigen. The polypeptides are synthesized by Escherichia coli bacterial strain produced by transforming PLT90 strain with pH 365 F recombinant plasmids possessing nucleotide sequence of Escherichia coli Cor-antigen gen. EFFECT: enhanced effectiveness in detecting hepatitis C virus antibodies and producing specific antibodies. 3 cl
| Title |
Year |
Author |
Number |
| DNA FRAGMENT HC 250 PREPARED BY CHEMICAL SYNTHESIS, RECOMBINANT POLYPEPTIDE HC 250 OF MOLECULAR MASS 120-130 KDA SHOWING CAPABILITY TO BIND ANTIBODIES TO GENE-ENCODING PROTEIN NS3 OF HEPATITIS C VIRUS PREPARED BY CULTIVATION OF THE STRAIN OF BACTERIUM ESCHERICHIA COLI AND STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF RECOMBINANT POLYPEPTIDE HC 250 SHOWING CAPABILITY TO BIND ANTIBODIES TO GENE-ENCODING PROTEIN NS3 OF HEPATITIS C VIRUS |
1993 |
- Blinov V.M.
- Loparev V.N.
- Krasnykh V.N.
- Gol'Tsov V.A.
- Grinev A.A.
- Alatortseva G.I.
- Poletaeva N.N.
- Sukhanova L.L.
|
RU2073719C1 |
| DNA FRAGMENT HC 280 PREPARED BY CHEMICAL SYNTHESIS, RECOMBINANT POLYPEPTIDE HC 280 AT MOLECULAR MASS 120-130 KDA SHOWING CAPABILITY TO BIND ANTIBODIES TO GENE-ENCODING PROTEIN NS4 OF HEPATITIS C VIRUS PREPARED AT CULTIVATION OF THE STRAIN OF BACTERIUM ESCHERICHIA COLI - STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF RECOMBINANT POLYPEPTIDE HC 280 SHOWING CAPABILITY TO BIND ANTIBODIES TO GENE-ENCODING PROTEIN NS4 OF HEPATITIS C VIRUS |
1993 |
- Loparev V.N.
- Krasnykh V.N.
- Blinov V.M.
- Gol'Tsov V.A.
- Zverev V.V.
- Sukhanova L.L.
- Alatortseva G.I.
|
RU2073718C1 |
| METHOD OF SYNTHESIS OF POLYPEPTIDE ELICITING ANTIGENIC ACTIVITY OF HEPATITIS E VIRUS AND SET FOR ASSAY OF ANTIBODY RAISED TO HEPATITIS E PATHOGEN |
1998 |
- Alatortseva G.I.
- Gol'Tsov V.A.
- Grinev A.A.
- Zverev V.V.
- Sukhanova L.L.
- Titaev A.V.
|
RU2172346C2 |
| SET FOR ASSAY OF ANTIBODY TO THE HUMAN HEPATITIS C VIRUS (VARIANTS) |
1993 |
- Krasnykh V.N.
- Loparev V.N.
- Blinov V.M.
- Grinev A.A.
- Alatortseva G.I.
- Gol'Tsov V.A.
- Zajtsev I.Z.
- Sukhanova L.L.
- Zverev V.V.
- Poletaeva N.N.
|
RU2084527C1 |
| POLYPEPTIDE 1106 DESIGNATED FOR ASSAY OF ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS TYPE-1, FRAGMENT OF DNA H 1106 ENCODING POLYPEPTIDE 1106, RECOMBINANT PLASMID DNA PH 1106 ENCODING POLYPEPTIDE 1106, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE 1106 |
1992 |
- Sukhanova L.L.
- Alatortseva G.I.
- Gol'Tsov V.A.
- Alatortsev V.E.
- Zverev V.V.
- Poletaeva N.N.
- Blinov V.M.
- Grinev A.A.
- Krasnykh V.N.
|
RU2085586C1 |
| POLYPEPTIDE DESIGNED FOR ANTIBODY ASSAY TO HUMAN IMMUNODEFICIENCY VIRUS OF THE SECOND TYPE, DNA FRAGMENT HE206 ENCODING POLYPEPTIDE E206, RECOMBINANT PLASMID DNA PHE206 ENCODING POLYPEPTIDE E206, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE E206 |
1992 |
- Zajtsev I.Z.
- Sukhanova L.L.
- Sazonov A.Eh.
- Karaseva E.V.
- Alatortseva G.I.
- Gol'Tsov V.A.
- Andzhaparidze O.G.
- Grinev A.A.
- Alatortsev V.E.
- Zverev V.V.
- Poletaeva N.N.
- Blinov V.M.
- Pokrovskij V.V.
- Suvorova Z.K.
- Buravtsova E.V.
- Krasnykh V.N.
- Jakovlev A.G.
- Amiantova I.I.
- Pugach A.V.
- Alekseev S.B.
- Chizhova M.M.
- Maljushova V.V.
|
RU2043412C1 |
| POLYPEPTIDE P102 DESIGNATED FOR ANTIBODY ASSAY TO HUMAN IMMUNODEFICIENCY VIRUS TYPE-1, DNA HP102-FRAGMENT ENCODING POLYPEPTIDE P102, RECOMBINANT PLASMID DNA PH A102 ENCODING POLYPEPTIDE P102, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE P102 |
1992 |
- Zajtsev I.Z.
- Sukhanova L.L.
- Alatortseva G.I.
- Gol'Tsov V.A.
- Grinev A.A.
- Alatortsev V.E.
- Zverev V.V.
- Poletaeva N.N.
- Blinov V.M.
- Noskova O.V.
- Lobanova A.L.
- Pokrovskij V.V.
- Suvorova Z.K.
- Buravtsova E.V.
- Krasnykh V.N.
|
RU2071502C1 |
| POLYPEPTIDE E117 DESIGNED FOR ANTIBODY ASSAY TO THE HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE, DNA FRAGMENT HE117 ENCODING POLYPEPTIDE E117, RECOMBINANT PLASMID DNA PHE117 ENCODING POLYPEPTIDE E117, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE E117 |
1992 |
- Zajtsev I.Z.
- Zvonarev A.Ju.
- Sukhanova L.L.
- Sazonov A.Eh.
- Karaseva E.V.
- Alatortseva G.I.
- Amiantova I.I.
- Gol'Tsov V.A.
- Andzhaparidze O.G.
- Alatortsev V.E.
- Zverev V.V.
- Poletaeva N.N.
- Blinov V.M.
- Titaev A.V.
|
RU2043413C1 |
| POLYPEPTIDE G103 DESIGNED FOR ANTIBODY ASSAY TO HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE, DNA FRAGMENT HG103 ENCODING POLYPEPTIDE G103, RECOMBINANT PLASMID DNA PHG103 ENCODING POLYPEPTIDE G103, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE G103 |
1992 |
- Zajtsev I.Z.
- Zvonarev A.Ju.
- Sukhanova L.L.
- Sazonov A.Eh.
- Karaseva E.V.
- Alatortseva G.I.
- Amiantova I.I.
- Gol'Tsov V.A.
- Andzhaparidze O.G.
- Alatortsev V.E.
- Zverev V.V.
- Poletaeva N.N.
- Blinov V.M.
- Titaev A.V.
|
RU2043414C1 |
| RECOMBINANT PLASMID DNA PQ-F35 ENCODING FUSED POLYPEPTIDE F35 SHOWING ANTIGENIC AND IMMUNOGENIC PROPERTIES OF MARBURG VIRUS PROTEIN VP 35, METHOD OF ITS PREPARING AND STRAIN OF BACTERIUM ESCHERICHIA COLI - SUPERPRODUCER OF RECOMBINANT POLYPEPTIDE F35 |
1998 |
- Sorokin A.V.
- Razumov I.A.
- Kazachinskaja E.I.
- Kachko A.V.
- Ivanova A.V.
- Mishin V.P.
- Bukreev A.A.
- Belanov E.F.
- Loktev V.B.
- Netesov S.V.
|
RU2144565C1 |
