2-HYDROXY-1-NAPHTHYLMETHYLENEHYDRAZONE 5-NITRO-2-FURALDEHYDE SHOWING ANTIMICROBIAL ACTIVITY TO BACTERIA OF STAPHYLOCOCCUS GENUS Russian patent published in 1995 - IPC

Abstract RU 2043350 C1

FIELD: organic chemistry. SUBSTANCE: product: 2-hydroxy-1-naphthylmethylenehydrazone of 5-nitro-2-furaldehyde, empirical formula is C16H11N3O4, m. p. is 200-201 C (with decomposition), LD50 is above 1000 mg/kg, minimal inhibiting concentration is 0.07-1.25 mcg/ml, minimal bactericidal concentration is 0.07-1.25 mcg/ml that exceeds furazolidone effect by several times. Reagent 1: 2-hydroxy-1-naphthaldehyde hydrazone. Reagent 2: 5-nitrofurfurol. Process conditions: in ethanol medium, at 50 C. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 tbl

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RU 2 043 350 C1

Authors

Tsapkov V.I.

Burdenko T.A.

Samus' N.M.

Dates

1995-09-10Published

1992-01-09Filed