FIELD: chemistry.
SUBSTANCE: present invention relates to organic chemistry and specifically to novel biologically active indazole compounds: 3-(2-bromophenyl)-4,5,6,7-tetrahydroindazole hydrochloride (1a) and 3-benzyl-4,5,6,7-tetrahydroindazole hydrochloride (1b) of general formula: Ia, b (R=C6H4Br-2 (a), CH2C6H5 (b)). The invention also relates to an antimicrobial agent based on compounds of formula (1a) or (1b).
EFFECT: novel indazole derivatives having antibacterial activity are obtained.
2 cl, 1 tbl, 3 ex
Title |
Year |
Author |
Number |
3-(1-NAPHTHYLMETHYL)-4,5,6,7-TETRAHYDROINDAZOLE HYDROCHLORIDE EXHIBITING ANTIMICROBIAL PROPERTIES |
2011 |
- Pantjukhin Aleksej Aleksandrovich
- Pershina Natal'Ja Nikolaevna
- Mikhajlovskij Aleksandr Georgievich
- Vakhrin Mikhail Ivanovich
- Aleksandrova Galina Arsent'Evna
- Krylova Irina Olegovna
- Makhmudov Ramiz Ragibovich
|
RU2459808C1 |
3-(3,4-DIMETHOXYPHENYL)-4,5,6,7-TETRAHYDROINDAZOLE HYDROCHLORIDE, ANALGESIC AND ANTIMICROBIAL AGENT |
2012 |
- Pantjukhin Aleksej Aleksandrovich
- Balandina Svetlana Jur'Evna
- Aleksandrova Galina Arsent'Evna
- Makhmudov Ramiz Ragibovich
- Mikhajlovskij Aleksandr Georgievich
- Pershina Natal'Ja Nikolaevna
- Vakhrin Mikhail Ivanovich
|
RU2485105C1 |
4-(1-CYCLOHEPTA-2,4,6-TRIENYL)ANILINE AND CHLORIDE THEREOF, EXHIBITING ANTIMICROBIAL ACTIVITY |
2011 |
- Junnikova Lidija Petrovna
- Akent'Eva Tat'Jana Anatol'Evna
|
RU2479571C1 |
MONOHYDROCHLORIDES AND SODIUM SALTS OF TAUTOMERIC 5 (6)-ALKOXYCARBONYLAMINO-DERIVATIVES OF 2-ARYL-1-HYDROXYBENZIMIDAZOLE-3-OXIDE WITH HIGH ANTIFUNGAL ACTIVITY AND SYNTHESIS METHOD THEREOF |
2009 |
- Velikorodov Anatolij Valerievich
- Kovalev Vjacheslav Borisovich
- Degtjarev Oleg Vladimirovich
|
RU2427574C2 |
INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY |
2008 |
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Aleksandrova Galina Arsent'Evna
|
RU2383550C1 |
4,4,4-TRICHLOR-1-(4-CHLOROPHENYL)BUTANE-1,3-DIONE POSSESSING ANALGESIC AND ANTIMICROBIAL ACTIVITIES |
2015 |
- Lisovenko Natalja Jurevna
- Makhmudov Ramiz Ragibovich
- Balandina Svetlana Jurevna
|
RU2582236C1 |
5-METHYL-2-OXO-1-PHENYL-4-ETHOXYCARBONYL-2,3-DIHYDRO-1H-PYRROLE-3-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-ORTHO-HYDROXYPHENYL-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIMICROBIAL ACTIVITY WITH RESPECT TO GRAM-POSITIVE MICROFLORA AND METHOD FOR THEIR PREPARING |
2005 |
- Maslivets Andrej Nikolaevich
- Racheva Nadezhda L'Vovna
- Belevich Irina Olegovna
|
RU2294330C1 |
11,11-DIMETHYL-1-OXO-1,2,10,11-TETRAHYDROBENZO[h]PYRROLO-[2,1-a]-ISOQUINOLINE-2-SPIRO-2-(1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE MICROFLORA |
2005 |
- Maslivets Andrej Nikolaevich
- Bannikova Julija Nikolaevna
- Shkljaev Jurij Vladimirovich
- Rozhkova Julija Sergeevna
- Smirnova Aleksandra Sergeevna
- Aleksandrova Galina Arsent'Evna
|
RU2281286C1 |
5-PHENYL-2-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)IMINO-2H-FURAN-3-ONE, POSSESSING ANTIMICROBIAL AND ANALGETIC ACTIVITY |
2014 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
- Panchenko Aleksej Olegovich
- Balandina Svetlana Jur'Evna
|
RU2560521C1 |
METHOD OF PRODUCING 5-ARYL-3-PHENYL-2-OXASPIRO[5,6]DODEC-3-EN-1-ONES, EXHIBITING ANALGESIC ACTIVITY |
2011 |
- Kirillov Nikolaj Fedorovich
- Gavrilov Aleksandr Gennad'Evich
- Makhmudov Ramiz Ragibovich
- Mardanova Ljudmila Gennad'Evna
|
RU2461555C1 |