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IPC

C07D405/14(2006-01-01)

A61K31/416(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2005100679/04, 2005-01-11

(24)

Start date

2005-01-11

(22)

Actual filing date

2005-01-11

(45)

Published

2006-04-10

(72)

Inventor

Golikov Aleksej Gennad'EvichKriven'Ko Adel' PavlovnaBugaev Aleksej Anatol'EvichShub Gennadij MarkovichRajkova Svetlana Vladimirovna

(73)

Holder

Saratovskij Gosudarstvennyj Universitet Im. N.G. Chernyshevskogo

3-(5-NITROFURYL)-7-(5-NITROFURFURYLIDENE-3,3A,4,5,6,7-HEXAHYDRO-2H-INDAZOLE ELICITING ANTIBACTERIAL ACTIVITY WITH RESPECT TO BACTERIUM OF GENUS STAPHYLOCOCCUS Russian patent published in 2006 - IPC C07D405/14 A61K31/416 A61P31/04

Abstract RU 2273640 C2

FIELD: organic chemistry, antibacterial agents.

SUBSTANCE: invention relates to a novel heterocyclic compound, in particular, 3-(5-nitrofuryl)-7-(5-nitrofurfurylidene-3,3a,4,5,6,7-hexahydro-2H-indazole of the formula (1): that elicits an antibacterial activity with respect to bacterium of genus Staphylococcus and can be used in medicine. The compound of the formula 91) is prepared by reaction of 2,6-di-(5-nitrofurfurylidene)-cyclohexanone with hydrazine hydrate in propanol-2 medium. The yield is 80%, m. p. at 193-195°C, empirical formula is C₁₆H₁₄N₄O₆, LD₅₀ value at intraperitoneal administration is 500 mg/kg. This compound exceeds activity of furacilinum and furazolidone by 16 and 2-31 times, respectively. Invention provides preparing compound possessing the higher and selective antibacterial activity and low toxicity.

EFFECT: valuable properties of compound.

1 cl, 3 tbl, 1 ex

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RU 2 273 640 C2

Authors

Golikov Aleksej Gennad'Evich

Kriven'Ko Adel' Pavlovna

Bugaev Aleksej Anatol'Evich

Shub Gennadij Markovich

Rajkova Svetlana Vladimirovna

Dates

2006-04-10—Published

2005-01-11—Filed