FIELD: organic chemistry. SUBSTANCE: product: derivatives of glutathione-S-lower saturated acid of the general formula where R1 H; R2 H, lower alkyl, phenyl; R3 H, lower alkyl; R4 amino-group, lower alkoxy-group which can be substituted with phenyl, hydroxy-group; n 0 or 1. Reagent 1: glutathione. Reagent 2: organic monocarboxylic acid or its ester or amide: R2 A COOH where A divalent group taken from: -CH=CR3 or -(CH2X)n-CHX where n 0 or 1; if n 0 then X halogen; if n 1 then one of radicals X is halogen and other has meanings indicated above for R3. Interaction product if necessary is esterified or amidated. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 12 cl, 1 tbl
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Authors
Dates
1995-10-27—Published
1991-04-25—Filed