1-ALKYL-2-ACYLINDOLES AND METHODS OF THEIR SYNTHESIS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product of the formula (I) where R₁ CH₃,, C₂H₅, H-C₃H₇, H-C₄H₉, CH₂= CH-CH₂, CH = C-CH₂, , CH₃-C(Cl) = CH-CH₂,, C₆H₅CH₂;; R₂= C₆H₅,, 4-Br-C₆H₄, 4-Cl-C₆H₄, C₆H₅CH = CH;; R₃ H, COOH, COOR₁ where R₁ has meanings indicated above. Reagent 1: compounds of the general formula (II) or (III) where R₂ and R₃ have meanings indicated above. Reagent 2: halogenalkane of the formula R₁X where R₁ has meanings indicated above; X halogen. Reaction conditions: in superbasic medium using dimethylsulfoxide-water (9:1)-NaOH (5-10%), or under conditions of interphase catalysis at the molar ratio of compound (II) (III) halogenalkane triethylbenzylammonium chloride 1: (5-6):1. Synthesized compounds show antiinflammatory and antitumor effects and can be used as intermediate substances for synthesis of sedative drugs. EFFECT: improved method of synthesis. 6 cl