HETEROCYCLIC DERIVATIVES OR THEIR SALTS WITH ACIDS OR BASES Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: heterocyclic derivatives of the formula (I) where A O or S; B C or N; Z₁-C₁-C₂-alkylene or phenylene, Z₂-C₁-C₂-alkylene; W group NR₁R₂ where R₁ H or C₁-C₄-alkyl R₂-H, C₁-C₄-alkyl, group CONQ₁Q₂ or CSNQ₁Q₂ where Q₁-Q₂ and H or C₁-C₄-alkyl; SO₂Q₃ or COQ₃ where Q Q(3) C₁-C₄-alkyl; COOQ₄ where Q Q(4) C₁-C₄-alkyl; or R₁ and R₂ taken together with nitrogen atom form saturated heterocycle of morpholine, pyrrolidine, piperidine or 4-(C₁-C₃)-alkylpiperazine, or W N-oxide of amines NR₁R₂ where R₁ and R₂-C₁-C₃-alkyl; or W C₁-C₄-alkoxy or C₁-C₄-thioalkoxy-group; COOQ₅ where Q Q(5) C₁-C₅-alkyl; or W group CONQ₁Q₂, pyridyl or imidazolyl; R₃ is absent when B nitrogen atom or represents hydrogen atom, C₁-C₄-alkyl or halogen atom; Ar₁ phenyl which can be substituted for chlorine, C₁-C₄-alkyl, C₁-C₄-alkoxy, hydroxy-, carboxy-group, COOQ₆ where Q Q(6) C₁-C_4/ -alkyl; carboxyamido-group, cyano, amino, acetamino, nitro, trifluoromethyl, or Ar₁ thienyl, thienyl, indolyl, naphthyl, benzyl or cyclohexyl; Ar₁ and R₃ taken together form group of the formula (II) where Ar₂ quinolyl, indolyl or pyridyl which can be substituted for C₁-C₃-alkyl or chlorine, or their salts with acids or bases. EFFECT: improved method of synthesis. 9 cl, 6 tbl