4-AMINOPHENOL DERIVATIVES OR THEIR N-ALKYL OR SALT DERIVATIVES SHOWING ANTIINFLAMMATORY ACTIVITY Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 4-aminophenol of the formula (I) where R₁ group -C(O)YZ where Y a simple bond, O, -NR₇ or CO; Z H, pyridyl, phenyl that can be substituted for halogen, nitro, lower alkoxy or carboxy; lower alkyl which can be substituted for -OH, lower alkoxy, lower acyloxy, carboxy, lower alkoxycarbonyl, CONR₈, phenyl(lower)alkoxy, phenyl, halide, cyano or NR₁₀R₁₂; R₂, R₃, R₆ anf R₅ H, lower alkyl or alkenyl, lower alkoxy or halogen; R₄ and R₇ H or lower alkyl; X 4,5-dihydropyrazolyl or pyrazolyl which can be substituted for C₃-C₆-cycloalkyl or phenyl which can be substituted for trihaloidalkyl; R₈, R₉, R₁₀ and R₁₁ H, lower alkyl or benzylhydroxycarbonyl, or their N-acyl or salt derivatives. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 6 cl