FIELD: medicinal microbiology. SUBSTANCE: for preparing leptospirosis vaccine no containing rabbit protein new strain Leptospira interrogans "Rat 2" НИИЭМ No. 466 is proposed. Strain is able to multiply actively on semisynthetic medium with human protein and shows stable virulence and high immunogenicity. Leptospira strain allows to prepare leptospirosis vaccine purified off mammalian protein showing high antigenic and protective properties for human immunization against interohemorrhagic leptospirosis. EFFECT: improved method of vaccine preparing. 1 tbl
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