INACTIVATED COMBINED VACCINE AGAINST CATTLE INFECTIOUS RHINOTRACHEITIS, VIRUS DIARRHOEA, ROTA-, CORONAVIRUS DISEASE AND LEPTOSPIROSIS Russian patent published in 2010 - IPC A61K39/295 C12N7/08 A61P31/12 

FIELD: medicine.

SUBSTANCE: invention refers to biotechnology. The vaccine contains an active substance and target additives. The active substance is presented with mixed inactivated suspensions of cattle infectious rhinotracheitis virus strain, SVC (State Virus Collection) No. 2333, Herpesviridae family, Alphaherpesviridae subfamily, inactivated suspension of cattle diarrhoea virus strain SVC No. 2336, Flaviviridae family, Pestivirus genus, inactivated suspension of cattle rotavirus strain, SVC No. 2337, Reoviridae family, Rotavirus genus, inactivated suspension of cattle coronavirus strain, SVC No. 2338, Coronaviridae family, Coronavirus genus with activity of each virus strain not less than 10^6.5 "ТЦД"₅₀ per 1 cm³ of the vaccine. As said active substance, the vaccine also contains mixed inactivated suspension of Leptospira interrogans bacteria cells of Pomona serogroup of strain VGNKI-6, inactivated suspension of Leptospira interrogans bacteria cells of Tarassovi serogroup of strain VGNKI-4, inactivated suspension of Leptospira interrogans bacteria cells of Grippotyphosa serogroup of strain VGNKI-1, inactivated suspension of Leptospira interrogans bacteria cells of Sejroe serogroup of Hardjo strain and inaktivirovannoj suspensions of cells of bacteria Leptospira interrogans of Sejroe serogroup of strain VGNKI-5 taken in the ratio equal to final concentration of each Leptospira strain not less than 270 million microbial cells per 1 cm³ of the vaccine. The vaccine is intended for prevention of cattle infectious diseases accompanied by reproductive disorders of various severities.

EFFECT: vaccine is better than common vaccines in the spectrum of specific protection and effectiveness for tolerant group of animals, duration of intense immunity, harmlessness for incalvers and newborn calves, stability of biological properties, including antigen and immunogen activity throughout 18 months (follow-up period).

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