STRAIN OF BACTERIUM LEPTOSPIRA INTERROGANS "MITRONOV" OF SERUM GROUP CANICOLA FOR PREPARING VACCINE Russian patent published in 2004 - IPC

FIELD: medicinal biotechnology, microbiology, vaccines. SUBSTANCE: invention can be used for preparing vaccine against leptospirosis. The strain L. interrogans is isolated from patient blood with leptospirosis. The strain heated at 56 C for 1 h elicits high immunogenic activity and protects experimental animals from death in administration to them of virulent leptospira in the dose that exceeds the lethal dose by 100-fold. Serum of animals immunized with experimental vaccine samples prepared from the strain "Mitronov" and containing antibodies raised against to leptospira of serum group Canicola exhibits high protective effect in experiment in golden hamster: ED₅₀ = 0.2. The strain is deposited in the collection NIIEM named for Hamalea AMS RF at = 480. Using the strain L. interragans = 480 provides preparing vaccine against epidemiologically actual pathogen of leptospirosis. EFFECT: valuable properties of strain and vaccine.