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2 054 041

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C1

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IPC

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Application

5023641/13, 1992-01-22

(22)

Actual filing date

1992-01-22

(45)

Published

1996-02-10

(72)

Inventor

Kravchenko V.V.Gileva I.P.Sandakhchiev L.S.Petrenko V.A.Korobko V.G.Dobrynin V.N.

(73)

Holder

Nauchno-Proizvodstvennoe Ob"Edinenie

RECOMBINANT PLASMID DNA PIF16 ENCODING THE MATURE HUMAN LEUCOCYTE α-INTERFERON, THE STRAIN OF ESCHERICHIA COLI - A PRODUCER OF THE MATURE HUMAN LEUCOCYTE a-INTERFERON Russian patent published in 1996 - IPC

Abstract RU 2054041 C1

FIELD: biotechnology. SUBSTANCE: new recombinant plasmid pIF16 has the tandem of two interferon genes between of which the synthetic cistron orf-69 consisting of 69 nucleotide residues is incorporated. This cistron encodes the constitutive synthesis of polypeptide showing properties of human leucocyte interferon. The strain of E. coli SG 20050/pIF 16 provides the expression level of a U/ml cell suspension at cell density a cells/ml that is about 200-300 mg per 1 l cell suspension. Strain is deposited in All-Union Collection of industrial microorganisms at number ВКПМ B-5809. EFFECT: new recombinant plasmid indicated above. 3 cl, 3 dwg, 2 tbl

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RU 2 054 041 C1

Authors

Kravchenko V.V.

Gileva I.P.

Sandakhchiev L.S.

Petrenko V.A.

Korobko V.G.

Dobrynin V.N.

Dates

1996-02-10—Published

1992-01-22—Filed

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