RECOMBINANT PLASMID DNA P280 GM ENCODING POLYPEPTIDE SHOWING PROPERTY OF HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR, STRAIN OF ESCHCERICHIA COLI SG 20050/P 280 GM - A PRODUCER OF POLYPEPTIDE SHOWING PROPERTY OF HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR Russian patent published in 1997 - IPC

Abstract RU 2091488 C1

FIELD: biotechnology, genetic engineering. SUBSTANCE: invention proposes new recombinant plasmid p280 GM containing gene for granulocyte-macrophage colony-stimulating factor that determines constitutive synthesis of polypeptide showing property of human granulocyte-macrophage colony-stimulating factor and the strain of Escherichia coli SG 20050/p280 GM providing the level of expression of this factor about 15% of total cellular protein at density 10⁹ cells/ml that is about 20-30 mg/l cellular suspension. EFFECT: enhanced effectiveness of factor producing. 2 cl, 3 dwg

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RU 2 091 488 C1

Authors

Gileva I.P.

Bondar' T.S.

Korobko V.G.

Kravchenko V.V.

Sandakhchiev L.S.

Dates

1997-09-27—Published

1994-03-16—Filed