FIELD: medicine. SUBSTANCE: desired products are prepared by ethynylation of 2-methyl-trans-decahydroquinolone-4. The process is carried out at 70-75 C in liquid ammonia in the presence of potassium hydroxide. Said process is followed by methylation with mixture of formaldehyde and formic acid and by neutralization of reaction mixture with potassium carbonate. Desired product is then isolated in free form or as salt. EFFECT: improves efficiency of method.
| Title | Year | Author | Number |
|---|---|---|---|
| PROCESS FOR PREPARING 2@-METHYL-TRANS-DECAHYDROQUINOLONE-4 | 0 |
|
SU1797608A3 |
| 1,2E-DIMETHYL-4A-(4'-HYDROXYBUTANOYL-1')-TRANS-DECAHYDROQUINOLOL-4 HYDROCHLORIDE EXHIBITING ANTIARHYTHMIC ACTIVITY AND METHOD OF ITS PREPARATION | 0 |
|
SU601937A1 |
| 5'1,2E-DIMETHYL-TRANS-DECAHYDROQUINOLINE-4-SPIRO-2'-/5'-OXYMETHYL-DELTA-3-DIHYDROFURAN POSITION/ EPIMERS HYDROCHLORIDES EXHIBITING ANTIARYTHMIC ACTIVITY AND THEIR PREPARATION METHOD | 0 |
|
SU675825A1 |
| 1,2E-DIMETHYL-TRANS-DECAHYDROQUINOLINE-4-SPIRO-2-TETRAHYDROPYRANONE-4 HYDROCHLORIDE EXHIBITING ANTIARYTHMIC ACTIVITY AND ITS PRODUCTION METHOD | 0 |
|
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