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(19)

(11)

2 811 864

(13)

(51)

IPC

A61K31/4545(2006-01-01)

A61K31/495(2006-01-01)

A61K31/50(2006-01-01)

A61K31/501(2006-01-01)

A61K31/5025(2006-01-01)

A61K31/503(2006-01-01)

A61K31/506(2006-01-01)

A61K31/537(2006-01-01)

A61K31/5377(2006-01-01)

A61P3/14(2006-01-01)

A61P5/18(2006-01-01)

A61P9/10(2006-01-01)

A61P13/12(2006-01-01)

(21) (22)

Application

2020139237, 2015-09-11

(24)

Start date

2015-09-11

(22)

Actual filing date

2015-09-11

(45)

Published

2024-01-18

(72)

Inventor

Ohtake YoshihitoOkamoto NaokiOno YoshiyukiKashiwagi HirotakaKimbara AtsushiHarada TakeoHori NobuyukiMurata YoshihisaTachibana KazutakaTanaka ShotaNomura KenichiIde MitsuakiMizuguchi EisakuIchida YasuhiroOhtomo ShuichiHoriba Naoshi

(73)

Holder

Chugai Seiyaku Kabushiki Kaisha

PHARMACEUTICAL PRODUCT CONTAINING INHIBITOR OF SODIUM DEPENDENT PHOSPHATE CARRIER Russian patent published in 2024 - IPC A61K31/4545 A61K31/495 A61K31/50 A61K31/501 A61K31/5025 A61K31/503 A61K31/506 A61K31/537 A61K31/5377 A61P3/14 A61P5/18 A61P9/10 A61P13/12

Abstract RU 2811864 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a pharmaceutical composition having inhibitory activity against one or more transporters selected from NaPi-IIb, PiT-1 and PiT-2, for use in the prevention or treatment of a disease selected from the group consisting of hyperphosphatemia, secondary hyperparathyroidism, chronic kidney disease and chronic renal failure or for use in the prevention or suppression of ectopic calcification, containing an effective amount of 7-[[2,3-difluoro-4-[2-[2-methoxyethyl(methyl)amino]ethoxy]phenyl]methyl]-10-hydroxy-6-methyl-8-oxo-N-[4-(trifluoromethyl)-2-[6-(trifluoromethyl)pyrimidin-4-yl]phenyl]-6,7-diazaspiro[4.5]dec-9-ene-9-carboxamide or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

EFFECT: prevention or treatment of hyperphosphatemia, secondary hyperparathyroidism, chronic kidney disease, chronic renal failure and the prevention or suppression of ectopic calcification, based on the use of a composition that inhibits one or more transporters selected from NaPi-IIb, PiT-1 and PiT-2.

22 cl, 49 tbl, 457 ex

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RU 2 811 864 C1

Authors

Ohtake Yoshihito

Okamoto Naoki

Ono Yoshiyuki

Kashiwagi Hirotaka

Kimbara Atsushi

Harada Takeo

Hori Nobuyuki

Murata Yoshihisa

Tachibana Kazutaka

Tanaka Shota

Nomura Kenichi

Ide Mitsuaki

Mizuguchi Eisaku

Ichida Yasuhiro

Ohtomo Shuichi

Horiba Naoshi

Dates

2024-01-18—Published

2015-09-11—Filed