2-SACCHARINYLMETHYLHETEROCYCLIC CARBOXYLATES OR THEIR BASIC ACID-ADDITIVE SALTS OR ACID BASIC-ADDITIVE SALTS AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES Russian patent published in 1997 - IPC

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: product: 2-saccharinylmethylheterocyclic carboxylates of the formula (I) $$$ where: Het - 5-, 6- or 9-membered bicyclic heterocycle containing 1-2 heteroatoms taken from: oxygen, sulfur or nitrogen, or the same heterocycles substituted with 1-3 similar or different members of group involving: lower alkyl, oxo-group, phenyl, halogen and -O-($$$-alkylene)-N=B where: N=B means di-(lower alkyl) or 4-morpholinyl; $$$ - H, lower alkyl or alkoxy, benzyloxy-group, lower alkoxycarbonyl, hydroxyl or phenyl; $$$ - H or one-two substituents at any of 5-, 6- or 7-position taken from lower alkyl or alkoxy, or their salts, and pharmaceutical composition on their base. Synthesized compounds inhibit activity of proteolytic enzymes. EFFECT: improved method of synthesis. 20 cl, 10 tbl