FIELD: organic chemistry. SUBSTANCE: for treatment of 6-aminopenicillanic acid brominating mixture is prepared preliminary. For this bromine and sodium nitrite were interacted in sulfuric acid solution or potassium bromide is interacted with concentrated nitric acid followed by dilution of interaction products with water. Then 6-aminopenicillanic acid in the form of an aqueous suspension or an aqueous suspension with alcohol added at amount 8.5 vol.% (not above as measured for total reaction mass volume) is added to prepared brominating mixture. EFFECT: improved method of synthesis.
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