2,3-DIHYDRO-5-HYDROXY-4,6,7-TRIMETHYLBENZOFURANS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND METHODS OF THEIR SYNTHESIS Russian patent published in 1996 - IPC

FIELD: organic chemistry. SUBSTANCE: product: 2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurans of the formula (I) where R and R₁- - as indicated above, or their pharmaceutically acceptable salts. Reagent 1: 2-(R, S)-2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranylacet- -ic acid or its methyl ester. Reagent 2: alkylating agent as dialkyl sulfate in alkaline solution, or alkylhalide in organic solvent solution, for example, tetrahydrofurane followed by reduction using methylaluminium hydride in tetrahydrofurane as reducing agent and the following conversion of one the end product to other one and its isolation as a free form or as pharmaceutically acceptable salt. Synthesized compounds were used as antioxidants and radical-accepting agent from pharmaceutical agents showing mucoregulating and antiischemic properties. EFFECT: improved method of synthesis. 4 cl, 6 tbl