DERIVATIVES OF 3-SUBSTITUTED 4-ARYLQUINOLIN-2-ONE AS MODULATORS OF POTASSIUM CHANNEL Russian patent published in 2004 - IPC

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention relates to new derivatives of 3-substituted 4-arylquinolin-2-one of the formula:

wherein each R and R¹ means independently hydrogen atom or methyl; each R², R³ and R⁴ means independently hydrogen atom or trifluoromethyl under condition that R², R³ and R⁴ are not hydrogen atom simultaneously; R⁵ means bromine or chlorine atom; R⁶ means hydrogen or fluorine atom; n means a whole number from 0 to 6; m means a whole number from 0 to 1; R⁷ means CH₃, CRR¹OH, CHO, C=NOH, COCH₃ or aryl substituted possibly with one or two substitutes taken among the group consisting of hydroxy-, methoxy-, amino- or acetylamino-group; or their nontoxic pharmaceutically acceptable salts. Invention provides preparing new compounds that are modulators of potassium channels with high conductivity and useful for treatment of disorders responsive to opening potassium channels.

EFFECT: valuable medicinal properties of compounds.

8 cl, 1 tbl, 47 ex