DERIVATIVES OF BENZIMIDAZOLONE, MIXTURE OF THEIR ISOMERS OR THEIR ACID ADDITIVE SALTS AS ANTAGONIST OF RECEPTOR 5HT AND 5HT Russian patent published in 1997 - IPC

FIELD: pharmacology. SUBSTANCE: derivatives of benzimidazolone have common formula given in specification where R₁ and R₂ are various and they represent hydrogen atom, halogen atom, trifluoromethyl, alkyl having 1-6 carbon atoms, alkoxy having 1-6 carbon atoms, alkylthio having 1-6 carbon atoms, acyl having 1-6 carbon atoms, carboxyl, alkoxycarbonyl having 1-6 carbon atoms, hydroxy, nitro group or amino group, unsubstituted or N-mono- or bisubstituted alkyl having 1-4 carbon atoms, acylamino having 1-6 carbon atoms, alkoxycarbonylamino having 1-6 carbon atoms, carbamoyl, unsubstituted or N-mono- or bisubstituted alkyl having 1-4 carbon atoms, cyano, alkylsulfynyl having 1-6 carbon atoms, alkylsulfonyl having 1-6 carbon atoms, aminosulfonyl, unsubstituted or N-mono- or bisubstituted alkyl having 1-4 carbon atoms or aminosulfonyl amino group, unsubstituted or N-mono- or bisubstituted alkyl having 1-4 carbon atoms; R₃ is hydrogen atom, alkyl having 1-6 carbon atoms, alkenyl having 2-6 carbon atoms or alkynyl having 2-6 carbon atoms; A is -CO- group or -CONH- group or A is absent; B is unbranched or branched, saturated or unsaturated alkyl having 2-6 carbon atoms; m and n are independently integer from 1 to 3; R₄ is phenyl, naphthyl or benzodioxane, unsubstituted or substituted by at least one substituent which is chosen of group comprising halogen atom, trifluoromethyl, cyano, alkoxy having 1-3 carbon atoms and alkyl having 1-4 carbon atoms. Derivatives, their individual isomers or mixture of their isomers and their acid additive salts have high biological activity. EFFECT: improved quality. 5 cl, 3 tbl