METHOD OF SYNTHESIS OF 2'-DEOXY-2'-FLUORORIBONUCLEOSIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 2'-deoxy-2'-fluororibonucleosides of the formula (I) or their pharmaceutically acceptable salts where Y H, NH₂, X-NR₃R₄ where R₃ and R₁ are both or separately H, C₁-C₆-alkyl, C₂-C₆-alkenyl C₃-C₇-cycloalkyl; X-Z-R₅ where Z O, S; R₅=R₃ or X O, H; R₁ and R₂ are both or separately OH, -OCOR₆H where R₆ alkyl-C₁-C₆-OR₆H or -OCOCHR₉NK₁₀R₁₁ where R₁₀ and R₁₁-H, n. or iso-C₁-C₆-alkyl, R₉-H, n. or iso-C₁-C₄-alkyl, or R₁ and R₂ mono-, di- or triphosphate ester group except for the case when R₁ and R₂ every OH, or R₁ mono-, di- or triphosphate 5′-ester group, and/or a) X OH, Y-NH₂, or b) X-NH₂, Y H. Reagent 1: purine base PuH where Pu compound of the formula Pu, X and Y as indicated above or its salt. Reagent 2: compound of the formula (II) where R and R as indicated above, W purine or pyrimidine different from Pu. Then the groups R_1/ and R₂ were converted to the other group, or R₁ and R₂ to OH-group. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 6 cl, 2 tbl