FIELD: organic chemistry. SUBSTANCE: product: derivatives of 2'-deoxy-2'-fluororibonucleosides of the formula (I) or their pharmaceutically acceptable salts where Y H, NH2, X-NR3R4 where R3 and R1 are both or separately H, C1-C6-alkyl, C2-C6-alkenyl C3-C7-cycloalkyl; X-Z-R5 where Z O, S; R5=R3 or X O, H; R1 and R2 are both or separately OH, -OCOR6H where R6 alkyl-C1-C6-OR6H or -OCOCHR9NK10R11 where R10 and R11-H, n. or iso-C1-C6-alkyl, R9-H, n. or iso-C1-C4-alkyl, or R1 and R2 mono-, di- or triphosphate ester group except for the case when R1 and R2 every OH, or R1 mono-, di- or triphosphate 5′-ester group, and/or a) X OH, Y-NH2, or b) X-NH2, Y H. Reagent 1: purine base PuH where Pu compound of the formula Pu, X and Y as indicated above or its salt. Reagent 2: compound of the formula (II)
where R and R as indicated above, W purine or pyrimidine different from Pu. Then the groups R1/ and R2 were converted to the other group, or R1 and R2 to OH-group. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 6 cl, 2 tbl
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Authors
Dates
1995-09-10—Published
1990-09-10—Filed