FIELD: as antiviral agents. SUBSTANCE: product: didesoxydidehydrocarbocyclic nucleoside of general formula 1: wherein X is H, Hal, NRR1,, -SR, -OR in which R and R1 and H or C1-4 alkyl; Z is H or NH2. Reagent 1: compound II in which X′ is halogen and Z is as defined above:
. Reagent 2: formic acid or derivative thereof such as trialkylchloroformate. Reaction conditions: in organic solvent (amides, chlorinated hydrocarbons, ethers, nitriles excess of reagent 2) at 25-150 C. EFFECT: improved properties of the antiviral agents. 5 cl
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Authors
Dates
1996-09-27—Published
1989-01-19—Filed