METHOD OF PREPARING PERFLUOROCARBON EMULSION FOR MEDICINAL AIMS Russian patent published in 1996 - IPC

Abstract RU 2070033 C1

FIELD: chemical technology. SUBSTANCE: invention relates to preparing emulsions which are able to transfer oxygen and used as blood-substituents, roentgencontrasting agents and for isolated organs storage. Mixture of perfluoroorganic compounds is dropped through an aqueous solution of emulsifying agent, then prepared preemulsion is passed by turns through the basic and additional homogenizer circulatory contour increasing pressure in additional contour by 1.1-1.2-fold as compared with pressure in basic contour. To prepare emulsions a mixture of perfluorodecaline or perfluorooctyl bromide and perfluoromethylcyclohexyl-piperidine is taken at ratio 2:1. Copolymer of polyoxyethylene-polyoxypropylene is used as emulsifying agent. Average particle size is from 0.06 to 0.11 mcm, particle part of size below 0.10 mcm is 85%. Emulsion is stored at t = +20 C for one month and for 3 months in frozen state. EFFECT: simplified technology, improved sterility of preparing monodispersed emulsion. 2 cl, 9 tbl, 1 dwg

Similar patents RU2070033C1

Title Year Author Number
GAS TRANSPORT PERFLUOROCARBON HAEMOCORRECTOR AND METHOD FOR PRODUCTION THEREOF 2021
  • Vorobev Sergej Ivanovich
RU2775474C1
COMPOSITION OF PERFLUOROCARBON BLOOD SUBSTITUTE BASED ON EMULSION OF PERFLUOROORGANIC COMPOUNDS FOR MEDICAL-BIOLOGICAL AIMS 2001
  • Vorob'Ev S.I.
RU2199311C2
METHOD FOR PRODUCTION OF SYNTHETIC PERFLUOROCARBON BLOOD SUBSTITUTING COMPOSITIONS AND OTHER MEDIA BASED ON PERFLUOROCARBON EMULSIONS 2004
  • Vorob'Ev Sergej Ivanovich
RU2307647C2
PERFLUORINATED GAS-TRANSFERRING EMULSION FOR MEDICAL AND BIOLOGICAL PURPOSES, COMPOSITION, METHOD OF OBTAINING AND PHARMACEUTICAL THEREOF (VERSIONS) 2006
  • Vorob'Ev Sergej Ivanovich
RU2367415C2
METHOD FOR OBTAINING SYNTHETIC PERFLUOROCARBON BLOOD SUBSTITUTES AND OTHER MEDIA BASED UPON PERFLUOROCARBON EMULSIONS 2004
  • Vorob'Ev Sergej Ivanovich
RU2308939C2
METHOD OF STERILE PERFLUOROCARBON EMULSIONS PREPARING FOR ARTIFICIAL PERFLUOROCARBON BLOOD SUBSTITUTES 2001
RU2200544C1
COMPOSITION BASED ON PERFLUOROORGANIC COMPOUND EMULSION FOR MEDICAL-BIOLOGICAL AIMS 1999
  • Vorob'Ev S.I.
  • Sklifas A.N.
  • Moiseenko O.M.
  • Svetlov V.N.
RU2162692C1
PERFLUORCARBON-FAT EMULSION WITH GAS-TRANSPORT AND ENERGY PROPERTIES FOR MEDICAL PRESCRIPTION: COMPOSITION, PRODUCTION METHOD AND THERAPEUTIC AGENT 2006
  • Vorob'Ev Sergej Ivanovich
RU2329788C2
PERFLUORINATED BLOOD SUBSTITUTE - GAS TRANSPORT DONOR BLOOD SUBSTITUTE: FORMULATION AND TREATMENT 2012
  • Vorob'Ev Sergej Ivanovich
RU2518313C2
PERFLUOROCARBONIC GAS-CARRYING EMULSION FOR MEDICO-BIOLOGICAL AIMS: METHOD OF OBTAINING BLOOD-SUBSTITUTING COMPOSITION 2009
  • Vorob'Ev Sergej Ivanovich
RU2415664C2

RU 2 070 033 C1

Authors

Vorob'Ev S.I.

Ivanitskij G.R.

Maevskij E.I.

Sklifas A.N.

Islamov B.I.

Shibaev N.V.

Belojartsev F.F.

Dates

1996-12-10Published

1994-11-28Filed