PROCESS FOR PREPARING CEPHALOSPORINIC ANTIBIOTICS Russian patent published in 1996 - IPC

FIELD: chemical and pharmaceutical industries. SUBSTANCE: process for preparing cephalosporinic antibiotics of formula 1 wherein R is H, t-Bu, is carboxy protecting group, Q is H, or (Ph)CH- is amino protecting group; Z is S or PhOCH₂CO; PHCH₂OCO is -CH₂- alkenyl. Reagent 1: 3-sulfonyloxy containing cephem derivative of formula II wherein Q and R are as defined above; Z is fluorosulfonytoxy, 4-nitrobenzenesulfonyloxy and 4- bromophenylsulfonyloxy. Reagent 2: organostannate of formula: R′ wherein R′Sn(R²)₃ is as defined above and R¹ is lower alkyl. Reaction conditions: aprotic solvent Pd(II) or Pd(0) catalyst in amount of 1-10 mole% per reagent 1. Structure of compounds of formulae I and II: R²-. EFFECT: improved properties of the cephalosporinic antibiotics.