METHOD OF SYNTHESIS OF CRYSTALLINE 7-[2-(2- AMINOTHIAZOLE-4-YL) -2-(Z)-METHOXYIMINOACETAMIDO]-3- [(-1-METHYL-1- PYRROLIDINIO) -METHYL]- CEPH-3-EM -4-CARBOXYLATE MONO- OR DIHYDRATE DIHYDROCHLORIDE ESSENTIALLY FREE FROM ANTIISOMER AND Δ-ISOMER Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: silylated derivative of the formula (I) where R and R′ every means hydrogen atom or silyl-protective group under condition that R and R′ simultaneously do not hydrogen atoms; X^x residue of hydrochloric, hydroiodic or sulfuric acid free of delta-(2)-isomer is interacted with syn-isomer of 2-(2-aminothiazole-4-yl)-2-methoxyiminoacetyl chloride hydrochloride essentially free of anti-isomer in inert organic solvent in the presence of base followed by isolation of the end product from prepared reaction mixture in the form of crystalline mono- or dihydrate dihydrochloride. EFFECT: improved method of synthesis. 19 cl, 4 dwg, 1 tbl