METHOD OF PREPARING CRYSTALLINE 7-[2-(2- AMINOTHIAZOLE-4-YL) -2(Z)-METHOXYIMINOACETAMIDO] -3-[(1- -METHYL -1-PYRROLIDINO) METHYL] -CEPH-3- EM-4-CARBOXYLATE DIHYDROCHLORIDE MONO- OR DIHYDRATE FREE FROM ANTIISOMER AND Δ-ISOMER Russian patent published in 1995 - IPC

Abstract RU 2039059 C1

FIELD: organic chemistry. SUBSTANCE: product: acid-additive salt of 7-amino-3- [(1-methyl -1-pyrrolidino) methyl] -ceph -4-carboxylate of the formula (I) where HX^- HCl, HJ or sulfuric acid free from Δ²-isomer is subjected for interaction with 2-(2-a minothazole-4-yl) -2-methoxyiminoacetyl-chloride hydrochloride free from antiisomer in aqueous-organic solvent at pH 5.0-7.5 following by isolation of the end product from the reaction mixture in the form of crystalline mono- or dihydrate dihydrochloride. EFFECT: improved method of preparing. 2 cl, 4 dwg, 1 tbl

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RU 2 039 059 C1

Authors

Gari M.F. Lim[Us]

Dzhon M. Roubaj[Us]

Dates

1995-07-09—Published

1992-09-09—Filed