CEPHEM OR CARBA(DETHIA)CEPHEM DERIVATIVES Russian patent published in 1995 - IPC

FIELD: in chemical and pharmaceutical industries as intermediates for the synthesis of cephalosporin antibiotics, more particularly compounds of the formula II wherein R₁-(C₂-C₆)-alkenyl, or CH₂, C₂H₅OCH₂CO, C₆H₅CH₂OCO, P-H, t-C₄H₉ and (C₂H₅)₂CH. SUBSTANCE: cephem of carba(dethia) cephem derivatives of the formula 1 wherein Z is as defined above, Q-C₆H₅OCH₂CO, C₆H₅CH₂OCO,P=t=C₄H₉ and (C₆H₅)₂CH. Reagent 1: oxysubstituted cephem or carba(dethia) cephem derivatives of the formula III wherein Z, Q and P are as defined above. Reagent 2: fluorosulfonic hydride. Reaction conditions: an organic solvent: 0-78 C in the presence of a base. The structural formulae I, II and III: . EFFECT: improved properties of the title compounds.