5-(2-4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL)ETHYL)-6- -CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE MONOHYDRATE AND PROCESS FOR PREPARATION THEREOF Russian patent published in 1997 - IPC

FIELD: chemistry of heterocyclic compounds with neuroleptic activity. SUBSTANCE: product 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl) ethyl)-6-6chloro-1,3-dihydro-2H-indol-2-one hydrochloride monohydrate has improved stability when preparaing compositions with neuroleptic activity. Monohydrate is prepared by reacting anhydrous 5-(2-(4-(1,2-benzisothiazol-3- -yl)1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one with hydrochloric acid having concentration preferably 0.3-3.0 M and more preferebably 0.7 M. EFFECT: higher efficiency. 5 cl, 6 dwg