FIELD: medicine. SUBSTANCE: described are new aminosubstituted pyrazoles of general formula: wherein R1-R3, A, Z and Y are as defined in claim 1. Said pyrazoles have antagonistic activity with respect to releasing factor of corticotropin. They are effective in treating wide range of diseases including stress induced disease. Also described are intermediate aminosubstituted pyrazines. EFFECT: improved properties of the title compounds. 13 cl, 36 ex, 4 tbl
Authors
Dates
1999-12-10—Published
1993-11-12—Filed