PYRAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pyrazole of the general formula (I) where means phenyl substituted with cyclo(lower)alkyl, hydroxy(lower)alkyl, cyano-, lower alkylenedihydroxy-, carboxy-, (lower alkoxy)carbonyl-group, lower alkanoyl, lower alkanoylhydroxy-, lower alkoxy-, phenoxy-group or carbamoyl optionally substituted with lower alkyl; R² means halogen, halo(lower)alkyl, cyano-, carboxy-, (lower alkoxy)carbonyl- -group, carbamoyl optionally substituted with alkyl; R³ means phenyl substituted with lower alkylthio-group, lower alkylsulfinyl- or lower alkylsulfonyl-group at condition that if R¹ means phenyl substituted with lower alkoxy-group then R² means halogen or halo(lower)alkyl, or their pharmaceutically acceptable salts. Synthesized compounds show antiinflammatory, antirheumatic and analgetic activity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 4 cl, 5 dwg, 3 tbl, 33 ex