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2 081 906

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C1

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IPC

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Application

94021756/13, 1994-06-15

(22)

Actual filing date

1994-06-15

(45)

Published

1997-06-20

(72)

Inventor

Kozlov Ju.I.Jomantas Ju.V.Plotnikova T.G.Perumov D.A.Frejdkin I.M.Sterkin V.Eh.Dedova O.A.Debabov V.G.

(73)

Holder

Gosudarstvennyj Nauchno-Issledovatel'Skij Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov

STRAIN OF BACTERIUM BACILLUS SUBTILIS - A PRODUCER OF RIBOFLAVIN Russian patent published in 1997 - IPC

Abstract RU 2081906 C1

FIELD: biotechnology, vitamins. SUBSTANCE: invention proposes new strain of bacterium Bacillus subtilis VKPM B-6797 as a producer of riboflavin. Strain-producer is obtained by insertion of recombinant plasmid carrying riboflavin operon of the strain Bacillus subtilis with the damaged negative regulation to the recipient strain Bacillus subtilis. Strain-producer shows resistance to 8-azaguanine, methionine-sulfoxide, diacetyl, psicofuranine and erythromycin and produces riboflavin at amount 12.4 g/l for 42 h culturing. EFFECT: enhanced productivity of the strain.

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RU 2 081 906 C1

Authors

Kozlov Ju.I.

Jomantas Ju.V.

Plotnikova T.G.

Perumov D.A.

Frejdkin I.M.

Sterkin V.Eh.

Dedova O.A.

Debabov V.G.

Dates

1997-06-20—Published

1994-06-15—Filed

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