FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of purine nucleoside 5'-aminoimidazole-4-carboxamide riboside (AICAR) and a Bacillus subtilis strain VKPM V-10167 - producer of AICAR. AICAR is obtained by culturing modified Bacillus subtilis bacteria in a suitable culturing medium. The modified bacteria used are Bacillus subtilis bacteria, obtained through successive introduction of mutations purR, purH::EmR, PurΔL and PrpsF-prs.
EFFECT: disclosed invention widens the range of methods for microbiological synthesis of AICAR and enables to engineering of the strain which produces AICAR for realising this method.
2 cl, 1 dwg, 2 tbl, 11 ex
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