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2 083 578

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C1

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IPC

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Application

95120964/04, 1995-12-14

(22)

Actual filing date

1995-12-14

(45)

Published

1997-07-10

(72)

Inventor

Sergeeva E.M.Minina S.A.Korbelajnen Eh.S.Kostin Ja.V.Kuznetsova V.A.Volkova N.D.

(73)

Holder

Sankt-Peterburgskij Khimiko-Farmatsevticheskij Institut

10-BR-N(4) PROPYLIMALINIUM BENZENESULFONATE HAVING ANTIARRHYTUMEL ACTIVITY Russian patent published in 1997 - IPC

Abstract RU 2083578 C1

FIELD: medicine, more particularly as antiarrythmic and antifibrillatory agent, said compound is synthesized from 10-Br- N(4)propylimalinium bromide with ionic exchange on anionite in benzene sulfonate ion form. SUBSTANCE: compound is essentially white odorless metallic powder, it is difficultly soluble in water and chloroform, and readily soluble in ethanol and methanol, mp 245-247c (decomp). Molecular weight is 605. Formula: C29H37N2O5SBr, [α]D20

= +72° (1 % solution in ethanol). Rf= 0.75+-0.02 (chloroform- acetone-diethylamine system (5: 4: 1), Rf=0.22+-0.02) (0.25% chloroform-methanol-ammonia system (90:10:0.2)). EFFECT: improved properties of the title compound. 4 tbl

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RU 2 083 578 C1

Authors

Sergeeva E.M.

Minina S.A.

Korbelajnen Eh.S.

Kostin Ja.V.

Kuznetsova V.A.

Volkova N.D.

Dates

1997-07-10—Published

1995-12-14—Filed

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