FIELD: medicine.
SUBSTANCE: invention can find application in medical practice for correcting heart rhythm disturbance and concerns a method for producing Nibentane with amino acid of formula (1) by dissolving 4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide in ethanol; the prepared solution is added with a glutamic acid solution in water at 50°C, then filtered, and 4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide glutaminate is recovered.
EFFECT: invention enables reducing toxicity and eliminating undesired side effects, as well as providing a broad therapeutic action.
4 tbl, 3 ex
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| PHARMACEUTICAL COMPOSITION POSSESSING PROLONGED ANTIARRHYTHMIC ACTIVITY | 2012 |
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| N-[2-(ADAMANT-2-YL)AMINOCARBONYLMETHYL]-N'-(DIALKYLAMINO)ALKYLNITROBENZAMIDES POSSESSING ANTIARHYTHMIC ACTIVITY | 2013 |
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| 2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ACETAMIDE L-GLUTAMATE, HAVING PROLONGED ANTIARRHYTHMIC ACTIVITY, PHARMACEUTICAL COMPOSITION | 2018 |
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| QUATERNARY AMMONIUM DERIVATIVE OF NOVOCAIN, WHICH POSSESSES ANTI-ARRHYTHMIC ACTIVITY, AND METHOD OF ITS OBTAINING | 2009 |
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| QUATERNARY AMMONIUM DERIVATIVE OF LIDOCAINE ELICITING ANTI-ARRHYTHMIC ACTIVITY AND METHOD FOR ITS PREPARING | 2004 |
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| APPLICATION OF GLUTARIC ACID DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AS ANTIARRHYTHMIC DRUG | 2008 |
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| SUCCINIC ACID ESTER 5-HYDROXYADAMANTAN-2-ONE, WHICH PREVENTS THE DEVELOPMENT OF CARDIAC ARRHYTHMIAS | 2020 |
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| PHARMACEUTICAL COMPOSITION WITH ANTIARRHYTHMIC ACTIVITY OF VARIOUS ETIOLOGIES | 2021 |
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| ANTIARRYTHMIC AGENT | 1983 |
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