QUATERNARY AMMONIUM DERIVATIVE OF LIDOCAINE ELICITING ANTI-ARRHYTHMIC ACTIVITY AND METHOD FOR ITS PREPARING Russian patent published in 2005 - IPC

Abstract RU 2258700 C1

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to a new biologically active compound. Invention describes quaternary ammonium derivative of lidocaine of the formula:

eliciting anti-arrhythmic activity. Also, invention describes a method for preparing quaternary ammonium derivative of lidocaine of the formula (1). Method involves interaction of N-(2,6-dimethylphenylaminocarbonylmethyl)-morpholine with allyl bromide in isopropyl alcohol medium at temperature 58-62°C followed by cooling the reaction mixture to room temperature and isolation of N-allyl-(2,6-dimethylphenylaminocarbonylmethyl)-morpholinium bromide. Invention provides preparing new compound eliciting useful biological properties.

EFFECT: improved preparing method.

2 cl, 4 tbl, 4 ex

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RU 2 258 700 C1

Authors

Blinov D.S.

Sernov L.N.

Balashov V.P.

Belova L.A.

Skachilova S.Ja.

Sharovarnikova L.A.

Shilova E.A.

Kazachenko V.N.

Astashov M.E.

Dates

2005-08-20Published

2004-06-28Filed