FIELD: organic chemistry, chemical technology, medicine, pharmacy.
SUBSTANCE: invention relates to a new biologically active compound. Invention describes quaternary ammonium derivative of lidocaine of the formula:
eliciting anti-arrhythmic activity. Also, invention describes a method for preparing quaternary ammonium derivative of lidocaine of the formula (1). Method involves interaction of N-(2,6-dimethylphenylaminocarbonylmethyl)-morpholine with allyl bromide in isopropyl alcohol medium at temperature 58-62°C followed by cooling the reaction mixture to room temperature and isolation of N-allyl-(2,6-dimethylphenylaminocarbonylmethyl)-morpholinium bromide. Invention provides preparing new compound eliciting useful biological properties.
EFFECT: improved preparing method.
2 cl, 4 tbl, 4 ex
Title | Year | Author | Number |
---|---|---|---|
QUATERNARY AMMONIUM DERIVATIVE OF NOVOCAIN, WHICH POSSESSES ANTI-ARRHYTHMIC ACTIVITY, AND METHOD OF ITS OBTAINING | 2009 |
|
RU2414893C1 |
PHARMACEUTICAL COMPOSITION POSSESSING PROLONGED ANTIARRHYTHMIC ACTIVITY | 2012 |
|
RU2538674C2 |
10-BR-N(4) PROPYLIMALINIUM BENZENESULFONATE HAVING ANTIARRHYTUMEL ACTIVITY | 1995 |
|
RU2083578C1 |
N-(2,4,6-TRIMETHYLPHENYLCARBAMOYLMETHYL)-N-ALLYLMORPHOLINIUM BROMIDE SHOWING ANTIISCHEMIC AND ANTIARRHYTHMIC EFFECTS AT ISCHEMIC HEART DISEASE AND A METHOD OF ITS SYNTHESIS | 1997 |
|
RU2105554C1 |
DERIVATIVE OF 4-HYDROXYBUTYRIC ACID BENZYLAMIDE SHOWING LOCAL ANESTHETIC, ANTIARRHYTHMIC, ANTIANGIAL AND ANTINECROTIC ACTIVITY | 1988 |
|
SU1601984A1 |
ANTIARRYTHMIC AGENT | 1983 |
|
RU2068261C1 |
COMPOUND OF NIBENTANE AND AMINO ACID POSSESSING ANTIARHYTHMIC ACTIVITY AND METHOD FOR PRODUCING IT | 2014 |
|
RU2572710C1 |
DICYCLOHEXYLAMIDES OF N-SUBSTITUTED ALFA-AMINOCARBOXYLIC ACIDS HAVING ANTIARRHYTMIC AND ANTIFIBRILLARY ACTIVITY | 1994 |
|
RU2114821C1 |
COMPOSITION OF AMINO ACIDS WITH TRACE ELEMENTS ELICITING ANTIARRHYTHMIC ACTIVITY | 1999 |
|
RU2173553C2 |
QUATERNARY AMMONIUM DERIVATIVES OF ACETIC ACID ANILIDES EXHIBITING ANTIARITHMIC ACTIVITY | 0 |
|
SU956463A1 |
Authors
Dates
2005-08-20—Published
2004-06-28—Filed