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Application

2004119597/04, 2004-06-28

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Start date

2004-06-28

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Actual filing date

2004-06-28

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Published

2005-08-20

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Inventor

Blinov D.S.Sernov L.N.Balashov V.P.Belova L.A.Skachilova S.Ja.Sharovarnikova L.A.Shilova E.A.Kazachenko V.N.Astashov M.E.

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Im. N.P. Ogareva"

QUATERNARY AMMONIUM DERIVATIVE OF LIDOCAINE ELICITING ANTI-ARRHYTHMIC ACTIVITY AND METHOD FOR ITS PREPARING Russian patent published in 2005 - IPC

Abstract RU 2258700 C1

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to a new biologically active compound. Invention describes quaternary ammonium derivative of lidocaine of the formula:

eliciting anti-arrhythmic activity. Also, invention describes a method for preparing quaternary ammonium derivative of lidocaine of the formula (1). Method involves interaction of N-(2,6-dimethylphenylaminocarbonylmethyl)-morpholine with allyl bromide in isopropyl alcohol medium at temperature 58-62°C followed by cooling the reaction mixture to room temperature and isolation of N-allyl-(2,6-dimethylphenylaminocarbonylmethyl)-morpholinium bromide. Invention provides preparing new compound eliciting useful biological properties.

EFFECT: improved preparing method.

2 cl, 4 tbl, 4 ex

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RU 2 258 700 C1

Authors

Blinov D.S.

Sernov L.N.

Balashov V.P.

Belova L.A.

Skachilova S.Ja.

Sharovarnikova L.A.

Shilova E.A.

Kazachenko V.N.

Astashov M.E.

Dates

2005-08-20—Published

2004-06-28—Filed

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