Patenton — panteon of patents

(19)

RU

(11)

2 414 893

(13)

C1

(51)

IPC

A61K31/166(2006-01-01)

C07C233/42(2006-01-01)

A61P9/06(2006-01-01)

(21) (22)

Application

2009141737/15, 2009-11-11

(24)

Start date

2009-11-11

(22)

Actual filing date

2009-11-11

(45)

Published

2011-03-27

(72)

Inventor

Blinov Dmitrij SergeevichBalashov Vladimir PavlovichSernov Lev NikolaevichBlinova Ekaterina ValerievnaBelova Ljudmila AleksandrovnaVal'Kova Ljudmila Vladimirovna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Im. N.P. Ogareva"

QUATERNARY AMMONIUM DERIVATIVE OF NOVOCAIN, WHICH POSSESSES ANTI-ARRHYTHMIC ACTIVITY, AND METHOD OF ITS OBTAINING Russian patent published in 2011 - IPC A61K31/166 C07C233/42 A61P9/06 

Abstract RU 2414893 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmacology and organic chemistry and deals with novel quaternary ammonium derivative of Novocain of formula which possesses anti-arrhythmic activity, and method of its obtaining by interaction of Novocain base with bromide allyl in medium of isopropyl alcohol at temperature 57-63°C, holding at said temperature during 5-6 hours with following cooling of reaction mixture to room temperature and separation of N-allyl-N-(2-oxiethylcarboxy-4-aminophenyl)-diethylamine of bromide.

EFFECT: compound possesses useful biological properties.

2 cl, 2 tbl

Similar patents RU2414893C1

Title Year Author Number
QUATERNARY AMMONIUM DERIVATIVE OF LIDOCAINE ELICITING ANTI-ARRHYTHMIC ACTIVITY AND METHOD FOR ITS PREPARING 2004
  • Blinov D.S.
  • Sernov L.N.
  • Balashov V.P.
  • Belova L.A.
  • Skachilova S.Ja.
  • Sharovarnikova L.A.
  • Shilova E.A.
  • Kazachenko V.N.
  • Astashov M.E.
 RU2258700C1
10-BR-N(4) PROPYLIMALINIUM BENZENESULFONATE HAVING ANTIARRHYTUMEL ACTIVITY 1995
  • Sergeeva E.M.
  • Minina S.A.
  • Korbelajnen Eh.S.
  • Kostin Ja.V.
  • Kuznetsova V.A.
  • Volkova N.D.
 RU2083578C1
COMPOUND OF NIBENTANE AND AMINO ACID POSSESSING ANTIARHYTHMIC ACTIVITY AND METHOD FOR PRODUCING IT 2014
  • Blinova Ekaterina Valerievna
  • Blinov Dmitrij Sergeevich
  • Singkh Larisa Nikolaevna
  • Elizarova Julija Nikolaevna
  • Ivanova Elena Anatol'Evna
  • Skachilova Sofija Jakovlevna
  • Zheltukhin Nikolaj Konstantinovich
 RU2572710C1
PHARMACEUTICAL COMPOSITION POSSESSING PROLONGED ANTIARRHYTHMIC ACTIVITY 2012
  • Skachilova Sofija Jakovlevna
  • Blinov Dmitrij Sergeevich
  • Zheltukhin Nikolaj Konstantinovich
  • Blinova Ekaterina Valerievna
  • Mitrokhin Nikolaj Mikhajlovich
  • Shilova Elena Vladimirovna
  • Storozhuk Irina Konstantinovna
 RU2538674C2
APPLICATION OF GLUTARIC ACID DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AS ANTIARRHYTHMIC DRUG 2008
  • Nebol'Sin Vladimir Evgen'Evich
  • Blinov Dmitrij Sergeevich
  • Balashov Vladimir Pavlovich
  • Kromova Tat'Jana Aleksandrovna
  • Zheltukhina Galina Aleksandrovna
 RU2373934C1
COMPOSITION OF AMINO ACIDS WITH TRACE ELEMENTS ELICITING ANTIARRHYTHMIC ACTIVITY 1999
  • Khafiz'Janova R.Kh.
  • Kostin Ja.V.
  • Shtyrlin V.G.
  • Zakharov A.V.
  • Nazmutdinova G.A.
  • Napalkova S.M.
  • Elaeva E.E.
  • Zaljaljutdinova L.N.
  • Sernov L.N.
  • Murzagaleeva G.N.
  • Kijasov A.P.
 RU2173553C2
SALTS OF MESIDIDES OF ALPHA-PIPERIDINCARBOXYLIC ACIDS POSSESSING LOCALLYANESTHETIC, ANTIARYTHMIC AND ANTIFIBRILLATORY ACTIVITY AND MESIDIDES OF ALPHA-PUPERIDINCARBOXYLIC ACIDS AS INTERMEDIATE PRODUCTS FOR SYNTHESIS OF SALTS OF MESIDIDES OF PIPERIDINCARBOXYLIC ACIDS 0
  • Pryanishnikova N.T.
  • Chernyakova I.V.
  • Burov Yu.V.
  • Kondaurov V.N.
  • Konobevtsev O.F.
  • Pyatin B.M.
  • Yavorskij A.N.
  • Lebedeva A.S.
  • Stavrovskaya A.V.
  • Kaverina N.V.
  • Berdyaev S.Yu.
  • Darinskij N.V.
  • Likhosherstov A.M.
  • Anyukhovskij E.P.
  • Rozenshtraukh L.V.
  • Beloshapko G.G.
  • Skoldinov A.P.
  • Rodionov A.P.
  • Efros M.B.
  • Dzhaparidze M.M.
 SU1120654A1
DERIVATIVE OF 4-HYDROXYBUTYRIC ACID BENZYLAMIDE SHOWING LOCAL ANESTHETIC, ANTIARRHYTHMIC, ANTIANGIAL AND ANTINECROTIC ACTIVITY 1988
  • Tjukhteneva Z.I.
  • Badovskaja L.A.
  • Tlekhusezh M.A.
  • Linchenko S.N.
  • Bartashevich V.V.
  • Mingalev A.N.
  • Khan V.V.
  • Uvarov A.V.
  • Vas'Kov K.S.
  • Medvedev O.S.
  • Stoljarchuk A.A.
  • Galenko-Jaroshevskij A.P.
  • Ehgik'Jan A.L.
  • Timoshenko Ja.G.
  • Kubantsev A.V.
  • Shejkh-Zade Ju.R.
  • Budarin L.I.
  • Kriss E.E.
  • Arshinnikova L.L.
  • Frantsuzova S.B.
  • Tikhonova N.A.
  • Galenko-Jaroshevskij P.A.
  • Ljufi A.Ja.
  • Onopriev V.V.
  • Porotikov V.I.
  • Bukej T.I.
 SU1601984A1
DERIVATIVES OF AMINO ACIDS SHOWING ANTIARRHYTHMIC ACTIVITY 1999
  • Sernov L.N.
  • Skachilova S.Ja.
  • Kostin Ja.V.
  • Napalkova S.M.
  • Druzhinina V.V.
  • Artem'Eva O.V.
 RU2164512C1
N-[2-(ADAMANT-2-YL)AMINOCARBONYLMETHYL]-N'-(DIALKYLAMINO)ALKYLNITROBENZAMIDES POSSESSING ANTIARHYTHMIC ACTIVITY 2013
  • Avdjunina Nina Ivanovna
  • Turilova Antonina Ivanovna
  • Pjatin Boris Mikhajlovich
  • Mirzojan Ruben Simonovich
  • Gan'Shina Tamara Sergeevna
  • Bol'Shakova Raisa Filippovna
  • Grushevskaja Ljubov' Nikolaevna
  • Alekseev Konstantin Viktorovich
  • Zherdev Vladimir Pavlovich
 RU2547096C2

RU 2 414 893 C1

Authors

Blinov Dmitrij Sergeevich

Balashov Vladimir Pavlovich

Sernov Lev Nikolaevich

Blinova Ekaterina Valerievna

Belova Ljudmila Aleksandrovna

Val'Kova Ljudmila Vladimirovna

Dates

2011-03-27—Published

2009-11-11—Filed

download Download PDF read Similar patents