N-IMIDAZOLYL-DERIVATIVES OF THE SUBSTITUTED INDOLE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: N-imidazolyl-derivatives of the substituted indole of the formula (I) where: p = 1, 2; A - direct C₁-C₄-alkylene chain; B - simple bond or direct saturated C₂-C₄-hydrocarbon chain; Q - direct or branched saturated C₁-C₄-hydrocarbon chain; R₁ and R₂ - H or halogen; R₃ and R₅ - H or C₁-C₄-alkyl; R₄ means OR₆ or N(R₆R₇); R₆ and R₇ - H or C₁-C₄-alkyl; Reagent 1: compounds of the formula: . Reagent 2: compound of the formula: . Pharmaceutical composition has compound (I) at effective amount and suitable carrier and/or vehicle. Synthesized compounds were used in medicine since they inhibit TxA_2/ -synthase and show activity of antagonist of PGH₂/TxA₂-receptors. EFFECT: improved method of synthesis, enhanced effectiveness. 7 cl, 3 tbl